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Systematic reconstruction of RNA functional motifs with high throughput microfluidics
We present RNA-MITOMI, a microfluidic platform for integrated synthesis and functional assays across thousands of RNAs. The interaction of a comprehensive library of RNA mutants with stem loop binding protein precisely defined the RNA structural and sequence features that govern affinity. The functi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3863600/ https://ncbi.nlm.nih.gov/pubmed/23142872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2225 |
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