Experimental evidence for UNC-6 (netrin) axon guidance by stochastic fluctuations of intracellular UNC-40 (DCC) outgrowth activity

How the direction of axon guidance is determined is not understood. In Caenorhabditis elegans the UNC-40 (DCC) receptor mediates a response to the UNC-6 (netrin) guidance cue that directs HSN axon development. UNC-40 becomes asymmetrically localized within the HSN neuron to the site of axon outgrowt...

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Autores principales: Kulkarni, Gauri, Xu, Zhennan, Mohamed, Ahmed M., Li, Haichang, Tang, Xia, Limerick, Gerard, Wadsworth, William G.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863414/
https://ncbi.nlm.nih.gov/pubmed/24337114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20136346
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