Angiogenic capacity of M1- and M2-polarized macrophages is determined by the levels of TIMP-1 complexed with their secreted proMMP-9

A proangiogenic function of tissue-infiltrating monocytes/macrophages has long been attributed to their matrix metalloproteinase-9 zymogen (proMMP-9). Herein, we evaluated the capacity of human monocytes, mature M0 macrophages, and M1- and M2-polarized macrophages to induce proMMP-9-mediated angioge...

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Detalhes bibliográficos
Main Authors: Zajac, Ewa, Schweighofer, Bernhard, Kupriyanova, Tatyana A., Juncker-Jensen, Anna, Minder, Petra, Quigley, James P., Deryugina, Elena I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862278/
https://ncbi.nlm.nih.gov/pubmed/24174628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-501494
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