Inhibition of Mitochondrial Pyruvate Transport by Zaprinast Causes Massive Accumulation of Aspartate at the Expense of Glutamate in the Retina

Transport of pyruvate into mitochondria by the mitochondrial pyruvate carrier is crucial for complete oxidation of glucose and for biosynthesis of amino acids and lipids. Zaprinast is a well known phosphodiesterase inhibitor and lead compound for sildenafil. We found Zaprinast alters the metabolomic...

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Detalhes bibliográficos
Main Authors: Du, Jianhai, Cleghorn, Whitney M., Contreras, Laura, Lindsay, Ken, Rountree, Austin M., Chertov, Andrei O., Turner, Sally J., Sahaboglu, Ayse, Linton, Jonathan, Sadilek, Martin, Satrústegui, Jorgina, Sweet, Ian R., Paquet-Durand, François, Hurley, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861660/
https://ncbi.nlm.nih.gov/pubmed/24187136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.507285
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