Hypoxic Tumor Environments Exhibit Disrupted Collagen I Fibers and Low Macromolecular Transport

Hypoxic tumor microenvironments result in an aggressive phenotype and resistance to therapy that lead to tumor progression, recurrence, and metastasis. While poor vascularization and the resultant inadequate drug delivery are known to contribute to drug resistance, the effect of hypoxia on molecular...

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Bibliographic Details
Main Authors: Kakkad, Samata M., Penet, Marie-France, Akhbardeh, Alireza, Pathak, Arvind P., Solaiyappan, Meiyappan, Raman, Venu, Leibfritz, Dieter, Glunde, Kristine, Bhujwalla, Zaver M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3861360/
https://ncbi.nlm.nih.gov/pubmed/24349142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081869
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