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Chemical Analog-to-Digital Signal Conversion Based on Robust Threshold Chemistry and Its Evaluation in the Context of Microfluidics-Based Quantitative Assays

In this paper, we describe a nonlinear threshold chemistry based on enzymatic inhibition and demonstrate how it can be coupled with microfluidics to convert a chemical concentration (analog input) into patterns of ON or OFF reaction outcomes (chemical digital readout). Quantification of small change...

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Detalhes bibliográficos
Main Authors: Huynh, Toan, Sun, Bing, Li, Liang, Nichols, Kevin P., Koyner, Jay L., Ismagilov, Rustem F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860884/
https://ncbi.nlm.nih.gov/pubmed/24060606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4062882
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