OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma

Sorafenib has been used to treat advanced hepatocellular carcinoma (HCC), but the underlying molecular mechanisms remain controversial and why some patients do not respond to this therapy is poorly understood. In this study, we show that sorafenib triggers cell growth inhibition and apoptosis in HCC...

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Detalhes bibliográficos
Main Authors: Zhao, Xiangxuan, Tian, Changhai, Puszyk, William M, Ogunwobi, Olorunseun O, Cao, Mengde, Wang, Ton, Cabrera, Roniel, Nelson, David R, Liu, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860369/
https://ncbi.nlm.nih.gov/pubmed/23108376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2012.144
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