PXR-Mediated Upregulation of CYP3A Expression by Herb Compound Praeruptorin C from Peucedanum praeruptorum Dunn

We recently reported that Praeruptorin C effectively transactivated the mRNA, protein expression, and catalytic activity of CYP3A4 via the CAR-mediated pathway, but whether and how PC could affect the expression and catalytic activity of CYP3A4 via PXR pathway remains unknown. Therefore, in this stu...

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Hlavní autoři: Huang, Ling, Wu, Qian, Li, Yu-Hua, Wang, Yi-Tao, Bi, Hui-Chang
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3860132/
https://ncbi.nlm.nih.gov/pubmed/24379885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/156574
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