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The Unpluggable in Pursuit of the Undruggable: Tackling the Dark Matter of the Cancer Therapeutics Universe
The notion that targeted drugs can unplug gain-of-function tumor pathways has revitalized pharmaceutical research, but the survival benefits of this strategy have so far proven modest. A weakness of oncogene-blocking approaches is that they do not address the problem of cancer progression as selecte...
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| Format: | Artigo |
| Language: | Inglês |
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Frontiers Media S.A.
2013
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859984/ https://ncbi.nlm.nih.gov/pubmed/24377088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00304 |
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