New Therapeutic Approach: Diphenyl Diselenide Reduces Mitochondrial Dysfunction in Acetaminophen-Induced Acute Liver Failure

The acute liver failure (ALF) induced by acetaminophen (APAP) is closely related to oxidative damage and depletion of hepatic glutathione, consequently changes in cell energy metabolism and mitochondrial dysfunction have been observed after APAP overdose. Diphenyl diselenide [(PhSe)(2)], a simple or...

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Hauptverfasser: Carvalho, Nélson R., da Rosa, Edovando F., da Silva, Michele H., Tassi, Cintia C., Dalla Corte, Cristiane L., Carbajo-Pescador, Sara, Mauriz, Jose L., González-Gallego, Javier, Soares, Félix A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859582/
https://ncbi.nlm.nih.gov/pubmed/24349162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081961
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