Drug Delivery to the Brain by Focused Ultrasound Induced Blood-Brain Barrier Disruption: Quantitative Evaluation of Enhanced Permeability of Cerebral Vasculature Using Two-Photon Microscopy

Reversible and localized blood-brain barrier disruption (BBBD) using focused ultrasound (FUS) in combination with intravascularly administered microbubbles (MBs) has been established as a non-invasive method for drug delivery to the brain. Using two-photon fluorescence microscopy (2PFM), we imaged t...

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Main Authors: Nhan, Tam, Burgess, Alison, Cho, Eunice E., Stefanovic, Bojana, Lilge, Lothar, Hynynen, Kullervo
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859519/
https://ncbi.nlm.nih.gov/pubmed/24008151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.08.029
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