Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation

Ionizing radiation (IR) and germline mutations in the retinoblastoma tumor suppressor gene (RB1) are the strongest risk factors for developing osteosarcoma. Recapitulating the human predisposition, we found that Rb1(+/–) mice exhibited accelerated development of IR-induced osteosarcoma, with a laten...

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Autors principals: Kansara, Maya, Leong, Huei San, Lin, Dan Mei, Popkiss, Sophie, Pang, Puiyi, Garsed, Dale W., Walkley, Carl R., Cullinane, Carleen, Ellul, Jason, Haynes, Nicole M., Hicks, Rod, Kuijjer, Marieke L., Cleton-Jansen, Anne-Marie, Hinds, Philip W., Smyth, Mark J., Thomas, David M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859382/
https://ncbi.nlm.nih.gov/pubmed/24231354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70559
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