Essential Roles of PKA, iNOS, CD95/CD95L, and Terminal Caspases in Suppression of Eosinopoiesis by PGE2 and Other cAMP-Elevating Agents

Up- and downregulation of eosinopoiesis control pulmonary eosinophilia in human asthma. In mice, eosinopoiesis is suppressed in vitro by prostaglandin E2 (PGE2) and in vivo by diethylcarbamazine, through a proapoptotic mechanism sequentially requiring inducible NO synthase (iNOS) and the ligand for...

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Autori principali: de Luca, Bianca, Xavier-Elsas, Pedro, Barradas, Mônica, Luz, Ricardo A., Queto, Túlio, Jones, Carla, Arruda, Maria Augusta, Cunha, Thiago Mattar, Cunha, Fernando Queiroz, Gaspar-Elsas, Maria Ignez
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859205/
https://ncbi.nlm.nih.gov/pubmed/24376378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/208705
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