Retrograde Endocannabinoid Signaling Reduces GABAergic Synaptic Transmission to Gonadotropin-Releasing Hormone Neurons

Cannabinoids suppress fertility via reducing hypothalamic GnRH output. γ-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to GnRH cells that can be excitatory. We hypothesized that cannabinoids act via inhibiting GABAergic input. We performed loose-patch electr...

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Autors principals: Farkas, Imre, Kalló, Imre, Deli, Levente, Vida, Barbara, Hrabovszky, Erik, Fekete, Csaba, Moenter, Suzanne M., Watanabe, Masahiko, Liposits, Zsolt
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858799/
https://ncbi.nlm.nih.gov/pubmed/20926585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0638
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