Synthesis and in vivo evaluation of [(18)F]2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione ([(18)F]FECUMI-101) as an imaging probe for 5-HT(1A) receptor agonist in nonhuman primates

The 5-HT(1A)R partial agonist PET radiotracer, [(11)C]CUMI-101, has advantages over an antagonist radiotracer as it binds preferentially to the high affinity state of the receptor and thereby provides more functionally meaningful information. The major drawback of C-11 tracers is the lack of cyclotr...

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Main Authors: Majo, Vattoly J., Milak, Matthew S., Prabhakaran, Jaya, Mali, Pratap, Savenkova, Lyudmila, Simpson, Norman R., Mann, J. John, Parsey, Ramin V., Dileep Kumar, J. S.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858174/
https://ncbi.nlm.nih.gov/pubmed/23816046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.05.050
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