Elevated FGF21 secretion, PGC-1α and ketogenic enzyme expression are hallmarks of iron–sulfur cluster depletion in human skeletal muscle

Iron–sulfur (Fe-S) clusters are ancient enzyme cofactors found in virtually all life forms. We evaluated the physiological effects of chronic Fe-S cluster deficiency in human skeletal muscle, a tissue that relies heavily on Fe-S cluster-mediated aerobic energy metabolism. Despite greatly decreased o...

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Hauptverfasser: Crooks, Daniel R., Natarajan, Thanemozhi G., Jeong, Suh Young, Chen, Chuming, Park, Sun Young, Huang, Hongzhan, Ghosh, Manik C., Tong, Wing-Hang, Haller, Ronald G., Wu, Cathy, Rouault, Tracey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857942/
https://ncbi.nlm.nih.gov/pubmed/23943793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt393
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