Tumor versus Stromal Cells in Culture—Survival of the Fittest?

Two of the signature genetic events that occur in human gliomas, EGFR amplification and IDH mutation, are poorly represented in experimental models in vitro. EGFR amplification, for example, occurs in 40 to 50% of GBM, and yet, EGFR amplification is rarely preserved in cell cultures derived from hum...

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Main Authors: Talasila, Krishna M., Brekka, Narve, Mangseth, Kjersti, Stieber, Daniel, Evensen, Lasse, Rosland, Gro V., Torsvik, Anja, Wagner, Marek, Niclou, Simone P., Mahesparan, Rupavathana, Vintermyr, Olav K., Bjerkvig, Rolf, Nigro, Janice M., Miletic, Hrvoje
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857854/
https://ncbi.nlm.nih.gov/pubmed/24349039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081183
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