Autophagy proteins stabilize pathogen-containing phagosomes for prolonged MHC II antigen processing

Antigen preservation for presentation is a hallmark of potent antigen-presenting cells. In this paper, we report that in human macrophages and dendritic cells, a subset of phagosomes gets coated with Atg8/LC3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antig...

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Main Authors: Romao, Susana, Gasser, Nathalie, Becker, Andrea C., Guhl, Bruno, Bajagic, Milica, Vanoaica, Danusia, Ziegler, Urs, Roesler, Joachim, Dengjel, Jörn, Reichenbach, Janine, Münz, Christian
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2013
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857489/
https://ncbi.nlm.nih.gov/pubmed/24322427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308173
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