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Hypoxia Regulates the Expression of the Neuromedin B Receptor through a Mechanism Dependent on Hypoxia-Inducible Factor-1α

The neuromedin B receptor (NMB-R), a member of the mammalian bombesin receptor family, is frequently overexpressed in various tumors. In the present study, we found that exposure to hypoxic conditions increases the levels of NMBR mRNA and protein in breast cancer cells, which are tightly regulated b...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Park, Hyun-Joo, Kim, Mi-Kyoung, Kim, Su-Ryun, Bae, Soo-Kyung, Bae, Moon-Kyoung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857296/
https://ncbi.nlm.nih.gov/pubmed/24349381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082868
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