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Fluctuation Analysis: Can Estimates Be Trusted?
The estimation of mutation rates and relative fitnesses in fluctuation analysis is based on the unrealistic hypothesis that the single-cell times to division are exponentially distributed. Using the classical Luria-Delbrück distribution outside its modelling hypotheses induces an important bias on t...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3857183/ https://ncbi.nlm.nih.gov/pubmed/24349026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080958 |
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