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Fluctuation Analysis: Can Estimates Be Trusted?

The estimation of mutation rates and relative fitnesses in fluctuation analysis is based on the unrealistic hypothesis that the single-cell times to division are exponentially distributed. Using the classical Luria-Delbrück distribution outside its modelling hypotheses induces an important bias on t...

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Detalles Bibliográficos
Autor Principal: Ycart, Bernard
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857183/
https://ncbi.nlm.nih.gov/pubmed/24349026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080958
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