Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants

BACKGROUND: Selective pressure from either the immune response or the use of nucleoside analogs in antiviral therapy could be driving the emergence of HBV mutants. Because of the overlap of the open reading frame (ORF) S for the HBsAg and ORF P for viral polymerase, rtM204I and rtM204V mutations in...

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Detalhes bibliográficos
Main Authors: Zhang, Mingshun, Ge, Guohong, Yang, Yonglin, Cai, Xubing, Fu, Qiang, Cai, Jie, Huang, Zuhu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856468/
https://ncbi.nlm.nih.gov/pubmed/24053482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-292
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