Decreased antigenicity profiles of immune-escaped and drug-resistant hepatitis B surface antigen (HBsAg) double mutants

BACKGROUND: Selective pressure from either the immune response or the use of nucleoside analogs in antiviral therapy could be driving the emergence of HBV mutants. Because of the overlap of the open reading frame (ORF) S for the HBsAg and ORF P for viral polymerase, rtM204I and rtM204V mutations in...

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Hoofdauteurs: Zhang, Mingshun, Ge, Guohong, Yang, Yonglin, Cai, Xubing, Fu, Qiang, Cai, Jie, Huang, Zuhu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2013
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856468/
https://ncbi.nlm.nih.gov/pubmed/24053482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-292
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