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Development of Hematopoietic Stem Cell Based Gene Therapy for HIV-1 Infection: Considerations for Proof of Concept Studies and Translation to Standard Medical Practice

Over the past 15 years we have been investigating an alternative approach to treating HIV-1/AIDS, based on the creation of a disease-resistant immune system through transplantation of autologous, gene-modified (HIV-1-resistant) hematopoietic stem and progenitor cells (GM-HSPC). We propose that the e...

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Detalhes bibliográficos
Main Authors: DiGiusto, David L., Stan, Rodica, Krishnan, Amrita, Li, Haitang, Rossi, John J., Zaia, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856421/
https://ncbi.nlm.nih.gov/pubmed/24284880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v5112898
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