Adjuvant Chemotherapy With FOLFOX for Primary Colorectal Cancer Is Associated With Increased Somatic Gene Mutations and Inferior Survival in Patients Undergoing Hepatectomy for Metachronous Liver Metastases

OBJECTIVE: We hypothesized that metachronous colorectal liver metastases (CLM) have different biology after failure of oxaliplatin (FOLFOX) compared to 5-fluorouracil (5-FU) or no chemotherapy for adjuvant treatment of colorectal cancer (CRC). BACKGROUND: It is unclear whether patients treated with...

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Auteurs principaux: Andreou, Andreas, Kopetz, Scott, Maru, Dipen M., Chen, Su S., Zimmitti, Giuseppe, Brouquet, Antoine, Shindoh, Junichi, Curley, Steven A., Garrett, Christopher, Overman, Michael J., Aloia, Thomas A., Vauthey, Jean-Nicolas
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856177/
https://ncbi.nlm.nih.gov/pubmed/22968062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SLA.0b013e31826b4dcc
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