Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes

Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R). In contrast, regulatory T-cells express very little CD127 and thereby may be delinea...

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Hlavní autoři: Moniuszko, Marcin, Glowinska-Olszewska, Barbara, Rusak, Malgorzata, Jeznach, Marta, Grubczak, Kamil, Lipinska, Danuta, Milewski, Robert, Milewska, Anna Justyna, Dabrowska, Milena, Jablonska, Ewa, Kretowski, Adam, Gorska, Maria, Bodzenta-Lukaszyk, Anna, Bossowski, Artur
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856128/
https://ncbi.nlm.nih.gov/pubmed/24348676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/459210
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