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Two high-resolution structures of the human E3 ubiquitin ligase Siah1
Siah1 is an E3 ubiquitin ligase that contributes to proteasome-mediated degradation of multiple targets in key cellular processes and which shows promise as a therapeutic target in oncology. Structures of a truncated Siah1 bound to peptide-based inhibitors have been reported. Here, new crystallizati...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
International Union of Crystallography
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3855715/ https://ncbi.nlm.nih.gov/pubmed/24316825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309113031448 |
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