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Two high-resolution structures of the human E3 ubiquitin ligase Siah1

Siah1 is an E3 ubiquitin ligase that contributes to proteasome-mediated degradation of multiple targets in key cellular processes and which shows promise as a therapeutic target in oncology. Structures of a truncated Siah1 bound to peptide-based inhibitors have been reported. Here, new crystallizati...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Rimsa, Vadim, Eadsforth, Thomas C., Hunter, William N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: International Union of Crystallography 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855715/
https://ncbi.nlm.nih.gov/pubmed/24316825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309113031448
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