Treatment Response in Kawasaki Disease Is Associated with Sialylation Levels of Endogenous but Not Therapeutic Intravenous Immunoglobulin G

OBJECTIVES: Although intravenous immunoglobulin (IVIG) is highly effective in Kawasaki disease (KD), mechanisms are not understood and 10-20% of patients are treatment-resistant, manifesting a higher rate of coronary artery aneurysms. Murine models suggest that α2-6-linked sialic acid (α2-6Sia) cont...

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Autori principali: Ogata, Shohei, Shimizu, Chisato, Franco, Alessandra, Touma, Ranim, Kanegaye, John T., Choudhury, Biswa P., Naidu, Natasha N., Kanda, Yutaka, Hoang, Long T., Hibberd, Martin L., Tremoulet, Adriana H., Varki, Ajit, Burns, Jane C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855660/
https://ncbi.nlm.nih.gov/pubmed/24324693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081448
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