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Gle1 functions during mRNA export in an oligomeric complex that is altered in human disease
The conserved multifunctional protein Gle1 regulates gene expression at multiple steps: nuclear messenger (m)RNA export, translation initiation, and translation termination. A GLE1 mutation (Fin(Major)) is causally linked to human lethal congenital contracture syndrome-1 (LCCS1); however, the result...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3855398/ https://ncbi.nlm.nih.gov/pubmed/24243016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.023 |
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