Mice Deficient in Sfrp1 Exhibit Increased Adiposity, Dysregulated Glucose Metabolism, and Enhanced Macrophage Infiltration

The molecular mechanisms involved in the development of obesity and related complications remain unclear. Wnt signaling plays an important role in preadipocyte differentiation and adipogenesis. The expression of a Wnt antagonist, secreted frizzled related protein 1 (SFRP1), is increased in response...

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Main Authors: Gauger, Kelly J., Bassa, Lotfi M., Henchey, Elizabeth M., Wyman, Josephine, Bentley, Brooke, Brown, Melissa, Shimono, Akihiko, Schneider, Sallie S.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855156/
https://ncbi.nlm.nih.gov/pubmed/24339864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078320
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