Association between C677T Polymorphism of Methylene Tetrahydrofolate Reductase and Congenital Heart Disease: Meta-Analysis of 7,697 Cases and 13,125 Controls

BACKGROUND: Association between the C677T polymorphism of the methylene tetrahydrofolate reductase (MTHFR) gene and congenital heart disease (CHD) is contentious. METHODS AND RESULTS: We compared genotypes between CHD cases and controls, and between mothers of CHD cases and controls. We placed our r...

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Auteurs principaux: Mamasoula, Chrysovalanto, Prentice, R. Reid, Pierscionek, Tomasz, Pangilinan, Faith, Mills, James L., Druschel, Charlotte, Pass, Kenneth, Russell, Mark W., Hall, Darroch, Töpf, Ana, Brown, Danielle L., Zelenika, Diana, Bentham, Jamie, Cosgrove, Catherine, Bhattacharya, Shoumo, Riveron, Javier Granados, Setchfield, Kerry, Brook, J. David, Bu'Lock, Frances A., Thornborough, Chris, Rahman, Thahira J., Doza, Julian Palomino, Tan, Huay L., O'Sullivan, John, Stuart, A. Graham, Blue, Gillian, Winlaw, David, Postma, Alex V., Mulder, Barbara J.M., Zwinderman, Aelko H., van Engelen, Klaartje, Moorman, Antoon F.M., Rauch, Anita, Gewillig, Marc, Breckpot, Jeroen, Devriendt, Koen, Lathrop, G. Mark, Farrall, Martin, Goodship, Judith A., Cordell, Heather J., Brody, Lawrence C., Keavney, Bernard D.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855044/
https://ncbi.nlm.nih.gov/pubmed/23876493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.113.000191
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