Oxygen levels determine the ability of glucocorticoids to influence neutrophil survival in inflammatory environments

GCs are highly effective in treating a wide range of inflammatory diseases but are limited in their ability to control neutrophilic lung inflammation in conditions such as COPD. Neutrophil apoptosis, a central feature of inflammation resolution, is delayed in response to microenvironmental cues, suc...

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Detalhes bibliográficos
Main Authors: Marwick, John A., Dorward, David A., Lucas, Christopher D., Jones, Katie O., Sheldrake, Tara A., Fox, Sarah, Ward, Carol, Murray, Joanna, Brittan, Mairi, Hirani, Nik, Duffin, Rodger, Dransfield, Ian, Haslett, Christopher, Rossi, Adriano G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Leukocyte Biology 2013
Assuntos:
Inflammation, Extracellular Mediators, & Effector Molecules
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855024/
https://ncbi.nlm.nih.gov/pubmed/23964116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0912462
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