Arenarol isolated from a marine sponge abrogates endothelin-1-stimulated melanogenesis by interrupting MEK phosphorylation in normal human melanocytes

Using B16 melanoma cells for screening, we found that a marine sponge extract has a potent anti-pigmenting effect and identified arenarol as its major active compound. In normal human melanocytes (NHMs), arenarol significantly abrogated the endothelin 1 (EDN1) stimulated expression of tyrosinase, ty...

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Bibliografske podrobnosti
Main Authors: Choi, Bong-Keun, Cha, Byung-Yoon, Fujiwara, Takeshi, Kanamoto, Akihiko, Woo, Je-Tae, Ojika, Makoto, Imokawa, Genji
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2013
Teme:
JAACT Special Issue
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853638/
https://ncbi.nlm.nih.gov/pubmed/23636431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-013-9555-5
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