Infrared Microspectroscopy Detects Protein Misfolding Cyclic Amplification (PMCA)-induced Conformational Alterations in Hamster Scrapie Progeny Seeds

The self-replicative conformation of misfolded prion proteins (PrP) is considered a major determinant for the seeding activity, infectiousness, and strain characteristics of prions in different host species. Prion-associated seeding activity, which converts cellular prion protein (PrP(C)) into Prote...

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Hlavní autoři: Daus, Martin L., Wagenführ, Katja, Thomzig, Achim, Boerner, Susann, Hermann, Peter, Hermelink, Antje, Beekes, Michael, Lasch, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853259/
https://ncbi.nlm.nih.gov/pubmed/24163371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.497131
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