NF-κB Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense

Introduction. Since the NF-κB pathway regulates both inflammation and host defense, it is uncertain whether interventions targeting NF-κB would be beneficial in sepsis. Based on the kinetics of the innate immune response, we postulated that selective NF-κB inhibition during a defined time period aft...

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Bibliographic Details
Main Authors: Li, Hui, Han, Wei, Polosukhin, Vasilly, Yull, Fiona E., Segal, Brahm H., Xie, Can-Mao, Blackwell, Timothy S.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852536/
https://ncbi.nlm.nih.gov/pubmed/24347827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/503213
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