The Structure of the RLIP76 RhoGAP-Ral Binding Domain Dyad: Fixed Position of the Domains Leads to Dual Engagement of Small G Proteins at the Membrane

RLIP76 is an effector for Ral small GTPases, which in turn lie downstream of the master regulator Ras. Evidence is growing that Ral and RLIP76 play a role in tumorigenesis, invasion, and metastasis. RLIP76 contains both a RhoGAP domain and a Ral binding domain (GBD) and is, therefore, a node between...

Full description

Saved in:
Bibliographic Details
Main Authors: Rajasekar, Karthik V., Campbell, Louise J., Nietlispach, Daniel, Owen, Darerca, Mott, Helen R.
Format: Artigo
Language:Inglês
Published: Cell Press 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852207/
https://ncbi.nlm.nih.gov/pubmed/24207123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.007
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items