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Free somatostatin receptor fraction predicts the antiproliferative effect of octreotide in a neuroendocrine tumor model: implications for dose optimization

Somatostatin receptors (SSTRs) are highly expressed in well-differentiated neuroendocrine tumors (NET). Octreotide, an SSTR agonist, has been used to suppress the production of vasoactive hormones and relieve symptoms of hormone hypersecretion with functional NETs. In a clinical trial, an empiric do...

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Detalhes bibliográficos
Main Authors: Heidari, Pedram, Wehrenberg-Klee, Eric, Habibollahi, Peiman, Yokell, Daniel, Kulke, Matthew, Mahmood, Umar
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851652/
https://ncbi.nlm.nih.gov/pubmed/24080280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1199
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