Shotgun Proteomics and Biomarker Discovery

Coupling large-scale sequencing projects with the amino acid sequence information that can be gleaned from tandem mass spectrometry (MS/MS) has made it much easier to analyze complex mixtures of proteins. The limits of this “shotgun” approach, in which the protein mixture is proteolytically digested...

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Bibliographic Details
Main Authors: McDonald, W. Hayes, Yates, John R.
Format: Artigo
Language:Inglês
Published: IOS Press 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851423/
https://ncbi.nlm.nih.gov/pubmed/12364816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2002/505397
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