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Tribody: Robust Self-assembled Trimeric Targeting Ligands with High Stability and Significantly Improved Target-binding Strength
The C-terminal coiled-coil region of mouse and human cartilage matrix protein (CMP) self-assembles into a parallel trimeric complex. Here, we report a general strategy for the development of highly stable trimeric targeting ligands (tribody), against epidermal growth factor receptor (EGFR) and prost...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3851414/ https://ncbi.nlm.nih.gov/pubmed/24050811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400716w |
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