Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease

The single-chain variable fragment, scFv-h3D6, has been shown to prevent in vitro toxicity induced by the amyloid β (Aβ) peptide in neuroblastoma cell cultures by withdrawing Aβ oligomers from the amyloid pathway. Present study examined the in vivo effects of scFv-h3D6 in the triple-transgenic 3xTg-...

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Autori principali: Giménez-Llort, Lydia, Rivera-Hernández, Geovanny, Marín-Argany, Marta, Sánchez-Quesada, José L., Villegas, Sandra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851220/
https://ncbi.nlm.nih.gov/pubmed/23884018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.25424
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