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Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment

The therapeutic potential of scFv-h3D6 has recently been shown in the 3xTg-AD mice. A clear effect on amyloid β (Aβ) oligomers and certain apolipoproteins in the brain was found, but no effect was seen in the cerebellum. Here, cellular vulnerability of the 3xTg-AD cerebellum is described for the fir...

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Bibliografiske detaljer
Main Authors: Esquerda-Canals, Gisela, Marti, Joaquim, Rivera-Hernández, Geovanny, Giménez-Llort, Lydia, Villegas, Sandra
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851219/
https://ncbi.nlm.nih.gov/pubmed/23884149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.25428
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