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14-3-3ε antagonizes FoxO to control growth, apoptosis and longevity in Drosophila
Antagonism between growth-promoting and stress-responsive signaling influences tissue homeostasis and longevity in metazoans. The transcription factor FoxO is central to this regulation, affecting cell proliferation, stress responses, apoptosis, and longevity. Insulin/IGF signaling promotes FoxO pho...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3851013/ https://ncbi.nlm.nih.gov/pubmed/18665908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2008.00420.x |
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