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Large-scale multiple testing in genome-wide association studies via region-specific hidden Markov models
BACKGROUND: Identifying genetic variants associated with complex human diseases is a great challenge in genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) arising from genetic background are often dependent. The existing methods, i.e., local index of significance (LIS) an...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3850654/ https://ncbi.nlm.nih.gov/pubmed/24067069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-14-282 |
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