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A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity
We developed a novel method to spatiotemporally control activity of signaling molecules. A newly synthesized photocaged rapamycin derivative induced rapid dimerization of FKBP (FK-506 binding protein) and FRB (FKBP-rapamycin binding protein) upon UV irradiation. With this system and the spatially co...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3850177/ https://ncbi.nlm.nih.gov/pubmed/21142151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja108258d |
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