Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

Certain matrix metalloproteinases (MMP) are expressed within the fibrous areas surrounding acellular lipid cores of atherosclerotic plaques, suggesting that these proteinases degrade matrix proteins within these areas and weaken the structural integrity of the lesion. We report that matrilysin and m...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Halpert, I, Sires, U I, Roby, J D, Potter-Perigo, S, Wight, T N, Shapiro, S D, Welgus, H G, Wickline, S A, Parks, W C
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1996
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8790402/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.18.9748
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