Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line

Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, has shown promising results as a growth inhibitor of HER2-positive cancer cells in vitro. However, similar to other EGFR-targeting drugs, acquired resistance t...

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Detalhes bibliográficos
Main Authors: Lee, Yong Yook, Kim, Hwang-Phill, Kang, Min Jueng, Cho, Byoung-Kyu, Han, Sae-Won, Kim, Tae-You, Yi, Eugene C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849569/
https://ncbi.nlm.nih.gov/pubmed/24263233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2013.115
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