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Accurate single nucleotide variant detection in viral populations by combining probabilistic clustering with a statistical test of strand bias

BACKGROUND: Deep sequencing is a powerful tool for assessing viral genetic diversity. Such experiments harness the high coverage afforded by next generation sequencing protocols by treating sequencing reads as a population sample. Distinguishing true single nucleotide variants (SNVs) from sequencing...

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Main Authors: McElroy, Kerensa, Zagordi, Osvaldo, Bull, Rowena, Luciani, Fabio, Beerenwinkel, Niko
格式: Artigo
語言:Inglês
出版: BioMed Central 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848937/
https://ncbi.nlm.nih.gov/pubmed/23879730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-501
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