BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment

BACKGROUND: Bone morphogenetic protein 4 (BMP4) belongs to the transforming growth factor β (TGF-β) family of proteins. BMPs regulate cell proliferation, differentiation and motility, and have also been reported to be involved in cancer pathogenesis. We have previously shown that BMP4 reduces breast...

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Main Authors: Ampuja, Minna, Jokimäki, Riikka, Juuti-Uusitalo, Kati, Rodriguez-Martinez, Alejandra, Alarmo, Emma-Leena, Kallioniemi, Anne
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848934/
https://ncbi.nlm.nih.gov/pubmed/24053318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-429
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