Bradykinin-induced Ca(2+) signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y(12) receptors activation

BACKGROUND: Chronic musculoskeletal pain involves connective tissue remodeling triggered by inflammatory mediators, such as bradykinin. Fibroblast cells signaling involve changes in intracellular Ca(2+) ([Ca(2+)](i)). ATP has been related to connective tissue mechanotransduction, remodeling and chro...

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Detalhes bibliográficos
Main Authors: Pinheiro, Ana Rita, Paramos-de-Carvalho, Diogo, Certal, Mariana, Costa, Cristina, Magalhães-Cardoso, Maria Teresa, Ferreirinha, Fátima, Costa, Maria Adelina, Correia-de-Sá, Paulo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848849/
https://ncbi.nlm.nih.gov/pubmed/24047499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-70
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