Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25

BACKGROUND: HMLEs (HMLE-SNAIL and Kras-HMLE, Kras-HMLE-SNAIL pairs) serve as excellent model system to interrogate the effect of SNAIL targeted agents that reverse epithelial-to-mesenchymal transition (EMT). We had earlier developed a SNAIL-p53 interaction inhibitor (GN-25) that was shown to suppres...

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Detalhes bibliográficos
Main Authors: Azmi, Asfar S, Bollig-Fischer, Aliccia, Bao, Bin, Park, Bum-Joon, Lee, Sun-Hye, Yong-Song, Gyu, Dyson, Gregory, Reddy, Chandan K, Sarkar, Fazlul H, Mohammad, Ramzi M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848843/
https://ncbi.nlm.nih.gov/pubmed/24004452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-7-85
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