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Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks

BACKGROUND: Niemann-Pick type C1 disease (NPC1) is a rare progressive neurodegenerative disorder caused by mutations in the NPC1 gene. In this lysosomal storage disorder the intracellular transport and sequestration of several lipids like cholesterol is severely impaired, resulting in an accumulatio...

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Detaylı Bibliyografya
Asıl Yazarlar: Trilck, Michaela, Hübner, Rayk, Seibler, Philip, Klein, Christine, Rolfs, Arndt, Frech, Moritz J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848807/
https://ncbi.nlm.nih.gov/pubmed/24044630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-8-144
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