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Rate-dependent Ca(2+) signalling underlying the force-frequency response in rat ventricular myocytes: a coupled electromechanical modeling study

BACKGROUND: Rate-dependent effects on the Ca(2+) sub-system in a rat ventricular myocyte are investigated. Here, we employ a deterministic mathematical model describing various Ca(2+) signalling pathways under voltage clamp (VC) conditions, to better understand the important role of calmodulin (CaM)...

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Main Authors: Krishna, Abhilash, Valderrábano, Miguel, Palade, Philip T, Clark, John W
格式: Artigo
語言:Inglês
出版: BioMed Central 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848742/
https://ncbi.nlm.nih.gov/pubmed/24020888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4682-10-54
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